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Results for "

hybrid compound

" in MedChemExpress (MCE) Product Catalog:

16

Inhibitors & Agonists

1

Biochemical Assay Reagents

2

Natural
Products

1

Isotope-Labeled Compounds

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-107987
    CXCR7 modulator 1

    		CXCR Endocrinology
    CXCR7 modulator 1 (compound 25) is a potent and orally bioavailable peptoid hybrid CXCR7 modulator, with a Ki of 9 nM .
    CXCR7 modulator 1
  • HY-N7093
    Furaneol

    		Others Others
    Furaneol is mainly isolated from American grape (Vitis labrusca) and its hybrid grape. Furaneol is an important aroma compound in fruits and contribute to the strawberry-like note in some wines .
    Furaneol
  • HY-114669
    Polyoxin C

    		Others Others
    Polyoxin C, the hybrid compound of nucleosides and R-amino acids, is important as the C-terminal amino acid component of Nikkomycin .
    Polyoxin C
  • HY-145294
    ROCK2-IN-5

    		ROCK Neurological Disease
    ROCK2-IN-5 (compound 1d) is a hybrid compound containing structural fragments of the Rho kinase inhibitor fasudil and the NRF2 inducers caffeic and ferulic acids. ROCK2-IN-5 has good multitarget profile and good tolerability. ROCK2-IN-5 has the potential for thr research of Amyotrophic lateral sclerosis (ALS) with a SOD1 mutation .
    ROCK2-IN-5
  • HY-161340
    Anti-melanoma agent 2

    		Apoptosis Cancer
    Anti-melanoma agent 2 (Compound IId) is a steroid hybrid that effectively induces endoplasmic reticulum stress (ERS) and causes apoptosis. Anti-melanoma agent 2 shows anti-melanoma effects .
    Anti-melanoma agent 2
  • HY-N11880
    2-O-Sinapoyl makisterone A

    		COX Cancer
    2-O-Sinapoyl makisterone A (compound 2), a sinapinic acid-ecdysterone hybrid, is a selective inhibitor of COX-2. 2-O-Sinapoyl makisterone A significantly inhibits the expression of COX-2 protein .
    2-O-Sinapoyl makisterone A
  • HY-128346
    PQM130

    		Amyloid-β Neurological Disease
    PQM130, a Feruloyl-Donepezil Hybrid compound with brain penatration, is a multitarget agent candidate against the neurotoxicity induced by Aβ1-42 oligomer (AβO) and shows anti-inflammatory activity. PQM130 acts as a neuroprotective compound for anti-AD agent development .
    PQM130
  • HY-156188
    AChE-IN-41

    		Others Others
    AChE-IN-41 (Compound 2) is a compound of the Galantamine Memantine hybrid. AChE-IN-41 has the inhibition ability of cholinesterase. AChE-IN-41 shows higher plasma stability and comparable microsomal stability in vitro, while showing lower half-life and faster clearance in vivo .
    AChE-IN-41
  • HY-146174
    KCa1.1 channel activator-2

    		Potassium Channel Cardiovascular Disease
    KCa1.1 channel activator-2 (compound 3F), a Quercetin hybrid derivative, is a selective vascular KCa1.1 channel stimulator. KCa1.1 channel activator-2 exhibits potent myorelaxant activity .
    KCa1.1 channel activator-2
  • HY-162170
    Anti-inflammatory agent 72

    		NF-κB Keap1-Nrf2 p38 MAPK Inflammation/Immunology
    Anti-inflammatory agent 72 (compound 5) is a novel resveratrol derivative hybrid with benzoylhydrazine. Anti-inflammatory agent 72 shows anti-inflammatory and antioxidant activities by activating Nrf2 and inhibiting NF-κB p65/iNOS and MAPKs signaling pathways .
    Anti-inflammatory agent 72
  • HY-115970
    Tubulin inhibitor 21

    		Microtubule/Tubulin Cancer
    Tubulin inhibitor 21 (compound 6f), a chalcone- and melatonin- based hybrid, is a potent tubulin inhibitor. Tubulin inhibitor 21 induces a remarkable cytotoxic activity toward SW480 cells (IC50=0.26 μM) with lower effect against nonmalignant cells .
    Tubulin inhibitor 21
  • HY-W598230A
    m-PEG-NH2 hydrochloride (MW 2000)

    		Liposome Others
    m-PEG-NH2 (hydrochloride) (MW 2000) is a barrier permeation compound involved in the preparation of hybrid gels with adsorption and size exclusion chromatography (AdSEC) properties. m-PEG-NH2 helps AdSEC gels separate from complex biological mixtures such as blood, urine, sweat, and tears.
    m-PEG-NH2 hydrochloride (MW 2000)
  • HY-145908
    Antitumor agent-49

    		Others Cancer
    Antitumor agent-49 (Compound 10) is a Harmine derivative-furoxan hybrids containing NO donor, with antitumor activities. Antitumor agent-49 shows cytotoxic activity against HepG2 cells with an IC50 of 1.79 µM. Antitumor agent-49 produces high levels of NO in vitro .
    Antitumor agent-49
  • HY-W012998S1
    2,3-Pentanedione-13C2

    		Others Isotope-Labeled Compounds
    2,3-Pentanedione- 13C2 is 13C labeled Furaneol (HY-N7093). Furaneol is mainly isolated from American grape (Vitis labrusca) and its hybrid grape. Furaneol is an important aroma compound in fruits and contribute to the strawberry-like note in some wines .
    2,3-Pentanedione-13C2
  • HY-146173
    KCa1.1 channel activator-1

    		Potassium Channel Calcium Channel Cardiovascular Disease
    KCa1.1 channel activator-1 (compound 1E), a Quercetin hybrid derivative, is a selective vascular KCa1.1 channel channel stimulator. KCa1.1 channel activator-1 also displays CaV1.2 channel blocking activity. KCa1.1 channel activator-1 exhibits weak myorelaxant activity .
    KCa1.1 channel activator-1
  • HY-149958
    Antileishmanial agent-17

    		Parasite Infection
    Antileishmanial agent-17 is a coumarin hybrid compound with antileishmanial effects (IC50 <0.78 μM). Antileishmanial agent-17 is safe to normal VERO cells. Antileishmanial agent-17 binds to folate pathway enzymes pteridine reductase and DHFR-TS. And Antileishmanial agent-17 shows the most potent with IC50 value of 0.40 μM against promastigote and 0.68 μM against amastigote, respectivley.
    Antileishmanial agent-17

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